Improved Barnes circular maze performance in DIP/WISH-deficient mice. Measures of distance traveled (A), latency (B), and number of errors (C) related to the location of the escape tunnel during the course of the training period (days 1 - 7) in the Barnes circular maze test using 8 week-old wild-type (WT) and DIP/WISH KO (KO) mice. Distance was significantly shorter in KO mice. Time spent around each hole was measured in the probe trial (D). After reversal learning, probe test was conducted again (E), in which KO mice displayed behavioral perseveration.