Skip to main content
Figure 1 | Molecular Brain

Figure 1

From: DNA methylation-mediated control of learning and memory

Figure 1

Overview of mammalian cytosine methylation. In mammals, cytosine methylation is necessary for regulation of DNA sequences and the following gene expression patterns. DNMT1 is active on hemimethylated DNA, which assists the maintenance of genomic methylation. The recruitment of DNMT1 to hemimethylated DNA is mediated through its interaction with UHRF1. DNMT3A and DNMT3B function as de novo methyltransferases, and they methylate the cytosine of previously unmethylated CpG dinucleotides on both strands.

Back to article page

Molecular Brain

ISSN: 1756-6606