Post-training lesions of the dorsal hippocampus impair contextual fear LTM formation after 5 conditioning trials in αCaMKII autophosphorylation-deficient mice. Means ± s.e.m. are shown. a: Twenty-four hours after conditioning WT mice (Sham, n = 14 and Lesioned, n = 8) and αCaMKIIT286A mutants (Sham, n = 12 and Lesioned, n = 8) were sham treated or the dorsal hippocampus was lesioned. Seven days after lesioning the mice were tested for contextual fear LTM. There was no significant difference between the genotypes, but the hippocampal lesion significantly impaired the contextual LTM in both genotypes. b: Histological assessment of the dorsal hippocampal lesions for both genotypes. *, P < 0.05.