Contextual LTM formation after 5 conditioning trials is impaired in 18 month-old αCaMKII autophosphorylation-deficient mice. Means ± s.e.m. are shown. a: Eighteen-month-old WT mice (n = 10) and αCaMKIIT286A mutants (n = 10) were trained with five tone-shock pairings and tested for recent contextual LTM 24 hours after conditioning. The mutants showed significantly less freezing. b: The same mice as in a were tested for cued fear memory 24 hours after the context test. For both genotypes there was significant tone fear memory. **, P < 0.01.