Figure 4

Role of CREB-mediated transcription in the reconsolidation of spatial memory. (A) Experimental design. (B) Probe trial at day 3 (PT 1) (WT/VEH, n = 12; WT/TAM, n = 9; CREB^IR/VEH, n = 9; CREB^IR/TAM, n = 10). *P < 0.05, time spent in the TQ vs. time spent in the other quadrants by post hoc Newman-Keuls test after significant one-way ANOVA. (C) Probe trial at day 4 (PT 2). *P < 0.05, time spent in the TQ vs. time spent in the other quadrants by post hoc Newman-Keuls test after significant one-way ANOVA. ^#P < 0.05, comparisons of searching scores in the TQ among the experimental groups of mice. Error bars are SEM. Time spent (s) in target (T), adjacent left (L), adjacent right (R), and opposite (O) quadrants during the probe trial is shown.