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Figure 4 | Molecular Brain

Figure 4

From: Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Figure 4

( A ) Treatment from 1-4 weeks in vitro with 50 μM NAC significantly inhibited TRPM2 currents generated by 0.3 mM ADPR and an NMDAR stimulation protocol in cultures at 28 DIV ( p = 0.04). (B, C) Representative control and NAC traces. (D) A 48 hour treatment with 250 μM L-BSO significantly enhances TRPM2 currents generated with 1 mM ADPR with an NMDAR stimulation protocol in hippocampal pyramidal neurons at 2 weeks in vitro. (E, F) Representative control and L-BSO traces.

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