Transplantation and engraftment of neural progenitors derived from F-HD-iPSCs into the adult mouse brain. A: Neurospheres derived from F-HD-iPSCs expressing GFP prior to transplantation (phase contrast and fluorescence demonstrating GFP expression). B: A diagram illustrating neural progenitor cell transplantation. GFP-labeled neural progenitor cells were injected into the subventricular zone (SVZ) and migrated along the rostral migratory stream (RMS) to the olfactory bulb (OB). GFP and human nuclei antibody (HNA) positive neurons were detected in the RMS (C) at six weeks and in the OB (D) at eight weeks post-transplantation. E: NeuN+ GFP expressing cells exhibiting granule cell morphology were detected in the OB eight weeks post-transplantation. Unless otherwise indicated, scale bars: 100 μm.