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Figure 6 | Molecular Brain

Figure 6

From: Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

Figure 6

Enhanced vacuoles formation in astrocytes after chloroquine treatment. A: Overnight treatment of astrocytes with the autophagy inhibitor chloroquine resulted in increased cytoplasmic vacuolation for all cell lines examined, with D-HD-astrocytes exhibiting the largest number of vacuoles. B: S100β expressing astrocytes exhibited increased cytoplasmic staining with the autophagic vacuole marker LC3, after treatment with chloroquine. Scale bar: 50 μm.

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