Figure 1

An interaction map of the known binding partners of the NCS proteins. The NCS protein family members are shown in yellow and binding partners in red with interactions directly with NCS proteins or between binding partners indicated. The edge colours indicate whether the interaction are with the Ca²⁺ -bound form (red) or the apo form (blue) or if this is not applicable (black). The binding partners and their abbreviations are as follows: Actin, Alsin, AP1 (clathrin adaptor), AP2 (clathrin adaptor), ARF1 (ADP-ribosylation factor-1), Calden (Caldendrin), CAPS (Ca²⁺-dependent activator protein for secretion), Cav1.2 (Ca²⁺ channel), Cav2.1 (Ca²⁺ channel), CALN (Calcineurin), Clathrin (Clathrin heavy chain), CREB (cAMP responsive element binding protein), CREM, (cAMP response element modulator), CTBP1/2 (C-terminal binding protein 1), cytb5 (cytochrome b5), D2R (dopamine D2 receptor), DAN (differential screening-selective gene aberrant in neuroblastome), GalT2 (galactosyl transferase 2), GluR6 (glutamate receptor 6), GRK1/2/6 (G protein-dependent receptor kinase 1/2/6), GUCY2A/2B/2D/2E (guanylate cyclase 2A/2B/2D/2E), HINT (histidine triad protein), ILIRAPL1 (interleukin receptor accessory protein like-1), IP3R (inositol 1, 4, 5 trisphosphate receptor), Kv1.5 (potassium channel), Kv4 (potassium channel), MLK2 (Mixed lineage kinase 2), NAIP (Neuronal apoptosis inhibitory protein), Nic a4b2 (nicotinic receptor containing 4 α and 2 β subunits), NR1 (NMDA receptor type 1), P2Y2R (purinergic receptor type 2Y2R), PDE (phosphodiesterase 1A), PI4KIIIb (phosphatidylinositol-4-kinase IIIβ), PICK1 (Protein interacting with C kinase 1), PINK1 (PTEN-induced kinase), prdx3 (Peroxiredoxin 3), PSD95 (post-synaptic density protein 95), PSEN1/2 (presenilin 1/2), ribeye (synaptic ribbon protein), S100b (S100 protein beta), SCAMC2 (Short calcium binding mitochondrial carrier 2), TGFbR1 (transforming growth factor β receptor type 1), TRPC1/5 (transient receptor potential channel 1/5), TSHR (thyroid stimulating hormone receptor), TTF-1 (Thyroid transcription factor 1), tubulin (α and β tubulin), ubc9 (Ubiquitin conjugating enzyme 9), VAMP2 (vesicle -associated membrane protein 2), VitDR (vitamin D receptor). Note that for simplicity we have used the name KChIP3 despite the fact that several of the original descriptions of the interactions used the alternative terminology of DREAM or calsenilin (see main text).