Figure 6

GABAergic synaptic transmission is low in the amygdala neurons of DBA mice. Spontaneous GABAergic inhibitory postsynaptic currents (IPSC) were recorded by whole-cell clamp at the amygdala neurons of brain slices from DBA/2 anxiety mice and control FVB/N mice. A) Left panels show sIPSCs recorded from FVB/N mice in top panel and sIPSCs with an extended time scale (bottom). Right panels show sIPSCs recorded from DBA/2 mice. B) shows cumulative probability vs. sIPSCs amplitudes from FVB/N mice (open symbols) and DBA/2 mice (filled ones) in an experiment of panel A. C) illustrates cumulative probability vs. intervals of events (sIPSCs) from FVB/N mice (open symbols) and DBA/2 mice (filled ones) in an experiment of panel A. D) shows cumulative probability vs. sIPSCs amplitudes in FVB/N mice (open symbols) and DBA/2 mice (filled) from all of the experiments (n = 12, p < 0.01). F) shows cumulative probability vs. intervals of events in FVB/N mice (open symbols) and DBA/2 mice (filled) averaged from all of the experiments (n = 11).