Figure 7

The agonist of metabotropic glutamate receptors, 3,5-dihydroxyphenylglycine (3,5-DHPG), improves anxiety-like behavior in DBA mice. An elevated plus-maze was used to evaluate anxiety-like behavior in two groups of DBA/2 mice that were given 3,5-DHPG (0.183 mg/kg) and PBS saline. A) shows the duration of staying in the closed arms vs. total duration for each experiment for DHPG-given mice (gray bar) versus PBS-given mice (white bar; p < 0.05, n = 9). B) shows exploration times toward the open arms in DHPG-given mice (gray bar) vs. PBS-given mice (white bar; p < 0.05, n = 9).