Figure 9

3,5-DHPG enhances GABAergic synaptic transmission in the amygdala neurons of DBA mice. Spontaneous GABAergic inhibitory postsynaptic currents (IPSC) were recorded by whole-cell clamp at amygdala neurons in brain slices before and after DHPG (10 μM) was washed onto the slices. A) shows GABAergic sIPSCs under the conditions of control (left panels) and DHPG application (right panels). Bottom panels show sIPSCs in the extended time scales. B) shows cumulative probability vs. sIPSCs amplitudes before (opened symbols) and after using DHPG (filled ones) from an experiment in panel A. C) shows the cumulative probability vs. inter-event intervals for sIPSCs before (opened symbols) and after applying DHPG (filled ones) from an experiment in panel A. D) shows the cumulative probability vs. sIPSCs amplitudes before (opened symbols) and after applying DHPG (filled ones) averaged from all of the experiments (n = 8). E) shows the cumulative probability vs. inter-event intervals for sIPSCs before (opened symbols) and after using DHPG (filled ones) from all of the experiments (n = 8, p < 0.01).