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Figure 3 | Molecular Brain

Figure 3

From: Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats

Figure 3

The analgesic effect of JNK inhibitor SP600125 on the nociceptive response to mechanical stimulations. (A) The paw withdrawal thresholds of ipsilateral side were significiantly decreased from day 5 until day 16. (B) The effect was tested immediately after a single intrathecal injection of SP600125 on day 12 after intra-tibial inoculation with carcinoma cells. (C) The accumulative (therapeutic) effect was tested 12 h after intrathecal injection of SP600125 on days 10, 12 and 14 after the intra-tibial inoculation of carcinoma cells. (D) The accumulative (therapeutic) effect was tested 24 h after intrathecal injection of SP600125 on day 10 and 14 after the intra-tibial inoculation of carcinoma cells. (* p < 0.05 and ** p < 0.01, compared to control, one-way ANOVA, Mean ± SEM n = 8)

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Molecular Brain

ISSN: 1756-6606