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Figure 2 | Molecular Brain

Figure 2

From: Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

Figure 2

Aβ1-42 oligomers prepared from a precursor isopeptide by direct dissolution in physiological buffer [50]inhibits long-term potentiation in the hippocampus in vivo . Animals were injected with either vehicle (open circles) or Aβ1-42 (2.5 μg, closed circles) by intracerbroventricular injection (asterisk) 10 min before the conditioning high frequency stimulation (HFS, arrow) in the CA1 area of the anaesthetized rat hippocampus. Values are the mean ± SEM baseline field EPSP (fEPSP) (n = 6-7 per group).

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