Figure 3
From: Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory
Aβ in soluble extracts of Alzheimer’s disease brain inhibits LTP in vivo . Representative example of LTP impairment after intracerebroventricular (i.c.v.) injection (asterisk) of Tris-buffered saline (TBS) extract of an AD brain containing Aβ (130 pg in total) (closed circles). In vehicle-injected controls, HFS (arrow) induces stable LTP (open circles) in the CA1 area of the anaesthetized rat.