Figure 4From: Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memoryThe aggregation-prone prion protein fragment PrP106-126 inhibits LTP in vivo . Animals were injected with either vehicle (open circles) or PrP106-126 (96 ng, closed circles) by i.c.v. injection (asterisk) 10 min before the HFS (arrow) in the CA1 area of the anaesthetized rat hippocampus. Values are the mean ± SEM baseline fEPSP (n = 10 per group).Back to article page