Figure 1

The probability of releasing glutamates increases during sequential presynaptic spikes in a linearly correlated manner. A) shows a diagram for the pair-recording of uEPSCs at unitary synapses from a pyramidal neuron to a GABAergic cell. B) shows synaptic responses evoked by five sequential spikes in a low glutamate release probability. Top traces show the superimposed traces of uEPSCs at a synapse, and a trace in bottom is sequential spikes evoked in presynaptic neuron. C) illustrates the averaged data of spikes vs. their corresponding release probability at this synapse. D) illustrates the averaged data of spikes vs. their corresponding release probability at other synapses (n = 26). E) shows the superimposed traces of uEPSCs and subsequent aEPSCs induced by sequential spikes 4 ~ 8 at a synapse. F) illustrates the averaged data of spikes vs. their corresponding aEPSCs frequency at this synapse. G) shows the averaged data of spikes versus their corresponding aEPSCs frequency at other synapses (n = 8). H) shows a plot of linear correlation between uEPSC1 ~ 8 amplitudes and their corresponding aEPSCs frequency (n = 8). Lines in E~F illustrate linear dynamical fitting.