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Figure 3 | Molecular Brain

Figure 3

From: Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes

Figure 3

The reduction of presynaptic Ca2+by infusing BAPTA attenuates the increment of release probability of glutamate release and the facilitation of synaptic transmission. A) Left panel shows the waveforms of uEPSC4 ~ 8 induced by sequential spikes (pointed by arrows) at a synapse under control. Calibration bar, 60 pA/100 ms. Right panel shows the waveforms of uEPSC4 ~ 8 induced by these sequential spikes (arrows) at this synapse under BAPTA infusion. Calibration bar, 30 pA/100 ms. B) shows the normalized uEPSC amplitudes under the conditions of control (opened symbols) versus BAPTA infusion (filled symbols; n = 10). C) shows the normalized probabilities of releasing glutamate under the conditions of control (opened symbols) versus BAPTA infusion (filled symbols; n = 10). It is noteworthy that the experiments were done at the synapses with low probability, such that uEPSC4 ~ 8 were analyzed. Lines in B and C illustrate linear dynamical fitting.

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