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Figure 10 | Molecular Brain

Figure 10

From: A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

Figure 10

Formic acid treatment reveals an increase in small 1C2+inclusions in the Hdh140Q/3xFlag20Qstriatum in comparison to Hdh140Q/3xFlag7Qstriatum. (A) Images of the striatum from 6 month-old and 2 year-old Hdh 140Q/3xFlag7Q and Hdh 140Q/3xFlag20Q mice probed with 1C2 antibody (red) following formic acid treatment. Nuclei were visualized with To-Pro-3. Examples of “aggregate chains” are indicated with white arrows. Scale bar = 25 μm. (B) Quantification of the total 1C2+ pixel area per microscopic field in the striatum of Hdh 140Q/3xFlag7Q and Hdh 140Q/3xFlag20Q mice at 6 months and 24 months of age (n=3 mice for each age and genotype, mean ± SEM). * P <0.05.

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