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Figure 7 | Molecular Brain

Figure 7

From: A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

Figure 7

The mean size of htt inclusions in the Hdh140Q/3xFlag20Qstriatum is significantly larger than that in the Hdh140Q/3xFlag7Qstriatum at 2 years of age. (A) Confocal images of the Hdh 140Q/3xFlag7Q and Hdh 140Q/3xFlag20Q striatum at 24 months of age. Htt inclusions were detected with the MW8 antibody (red) and nuclei with To-Pro-3 (blue). Scale bar = 25 μm. (B) Quantification of the average size (total MW8 + pixels/inclusion number per imaging field) of htt inclusions in the Hdh 140Q/3xFlag7Q and Hdh 140Q/3xFlag20Q striatum at 6 months and 24 months of age (n=3 for each age and genotype, mean ± SEM plotted). ** P <0.01.

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