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Table 1 Chi square analyses of genotypes produced from heterozygous and hemizygous crosses

From: A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

Genotype

# Observed (# Expected)

χ2(P)

Cross: Hdh3xFlag7Q/+ X Hdh3xFlag7Q/+

+/+

16 (23)

    1.69 (0.429)

3xFlag7Q/+

51 (46)

 

3xFlag7Q/3xFlag7Q

26 (23)

 

Cross: HdhHA7Q/+ X HdhHA7Q/+

+/+

16 (20)

    1.01 (0.603)

HA7Q/+

39 (40)

 

HA7Q/HA7Q

25 (20)

 

Cross: Hdh3xFlag20Q/+ X Hdh3xFlag20Q/+

+/+

6 (6)

0.0697 (0.966)

3xFlag20Q/+

12 (12)

 

3xFlag20Q/3xFlag20Q

5 (6)

 

Cross: Hdh3xFlag7Q/+ X Hdh+/-

+/+

2 (4)

    1.15 (0.765)

3xFlag7Q/+

6 (4)

 

3xFlag7Q/-

4 (4)

 

+/-

5 (4)

 

Cross: Hdh3xFlag140Q/+ X Hdh3xFlag140Q/+

+/+

9 (10)

    2.03 (0.362)

3xFlag140Q/+

24 (20)

 

3xFlag140Q/3xFlag140Q

5 (10)

 
  1. The observed and expected numbers of the homozygous and hemizygous progeny are in bold.
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Molecular Brain

ISSN: 1756-6606