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Figure 6 | Molecular Brain

Figure 6

From: Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Figure 6

LRRK2 accumulates in globules in αS tg mice . (a and b) Double immunofluorescence for αS with parkin, PINK1, DJ-1, LRRK2, or negative control (the immunopeptide-preabsorbed anti-LRRK2 antibody) in αS tg mice (a) and P123H ßS tg mice (b). Note that αS-globules were immunopositive for LRRK2 (~79%, n = 22), whereas P123H ßS globules were negative for LRRK2. Representative images are shown for the thalamus (αS) and basal ganglia (P123H ßS). Scale bar = 5 μm for all panels. (c) Triple immunofluorescence for αS, LRRK2 and Rab5B for basal ganglia in αS tg mice. LRRK2 and Rab5B were colocalized in axon terminal (arrow), but were not colocalized in the αS-globule (arrowhead) Scale bar = 10 μm for all panels.

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Molecular Brain

ISSN: 1756-6606