Skip to main content
Figure 3 | Molecular Brain

Figure 3

From: Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics

Figure 3

Effects of optical activation on background activity. Effect of optical stimulation with different light intensities (1, 5, 10 mW; 10 Hz) for 40–60 s on background activity of mPFC pyramidal cells. (A) Intensity-dependent activation of IL pyramidal cells by optical stimulation in IL. Left, Peristimulus time histograms (bin width, 1 s) show background activity of an individual neuron. Right, Bar histograms show summary data (means ± SE) for the sample of IL pyramidal cells (n = 9). Background activity was recorded before (Pre), during (1, 5 and 10 mW) and after (Post) optical stimulation. (B) Intensity-dependent inhibition of PL pyramidal cells by optical stimulation in IL. Left, PSTHs show background activity of an individual neuron. Right, Bar histograms show summary data (means ± SE) for the sample of PL pyramidal cells (n = 12). *, ** P < 0.05, 0.01 (compared to control before stimulation “Pre”, Dunnett’s multiple comparison tests).

Back to article page