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Table 1 Transgene rescue of the navigational phenotype by expressing a UAS- tutl transgene under control of cell-type-specific GAL4 drivers

From: Control of directional change after mechanical stimulation in Drosophila

GAL4 driver Expressing pattern Change in moving direction (°) (Mean±SEM) Rescue effect
C155-GAL4 All post-mitotic neurons 93.8±5.5 Ya
Appl-GAL4 Many PNS and CNS neurons 107.0±5.3 Y
Cha-GAL4 Cholinergic neurons in PNS and CNS 74.0±5.2 Y
OK371-GAL4 Glutamatergic neurons (motor neurons and neuronal clusters in the brain) _c Nb
Ddc-GAL4 Dopaminergic and serotonergic neurons 33.4±3.5 N
RN2-GAL4 RP2, aCC and pCC 38.4±3.7 N
G11-1-GAL4 Embryonic PNS 49.6±5.6 N Subsets of neurons 40.0±4.4 N
D42-GAL4 Motor neurons and PNS neurons 76.4±8.7 N
TrpA1-GAL4 CNS neurons expressing TrpA1 gene 51.1±6.9 N
5-HTR1B-GAL4 Neurons expressing serotonin receptor 1B 46.9±4.5 N
C81-GAL4 CNS neurons with diffuse expression throughout brain lobes 45.8±4.7 N
SN(5-40)-GAL4 All sensory neurons 56.6±5.1 N
NompC-GAL4 Class I , bd neurons and chordotonal organs 47.7±4.0 N
iav-GAL4 Chordotonal organs 46.2±3.5 N
Pain-GAL4 md neurons, chordotonal organs and some CNS neurons 52.1±4.7 N
ppk1.9-GAL4 Class IV da neurons 51.2±5.3 N
  1. 3rd-instar tutl23/tutl23 mutant larvae, in which UAS-tutl was under control of different cell-type-specific GAL4 drivers, were examined for navigational pattern in response to tactile stimuli. Their performance was compared to that of tutl23/tutl23 mutant larvae that only carry GAL4.
  2. a “Y” indicates significant rescue (p<0.05).
  3. b “N” indicates no significant rescue.
  4. c Expression of tutl under control of Ok371-GAL4 in tutl mutant larvae caused a failure for larvae to resume forward movement after gentle touch.