Figure 5

Impaired late-phase LTP and LTD in the mib1 cKO mice. (A) Normal synaptic transmission in mib1 cKO mice. The synaptic input–output relationship was obtained by plotting the fiber volley amplitude against the initial slope of the evoked fEPSP. (B) Normal paired-pulse response ratio in mib1 cKO mice. The graph depicts the paired-pulse response ratio (2nd fEPSP/1st fEPSP) obtained at different interstimulus intervals (in ms). (C) Normal E-LTP in mib1 cKO mice. Time course of the effects of 1 train of high-frequency stimulation (HFS) on the fEPSP initial slope. (D) Impaired L-LTP induced by four trains of tetanic stimulation in mib1 cKO mice. Time course of the effects of 4 X HFS stimulation on the fEPSP initial slope. (E) Impaired L-LTP in mib1 cKO mice. Time course of the effects of theta-burst stimulation (TBS) on the fEPSP initial slope. (F) Impaired LFS-LTD in mib1 cKO mice. Time course of the effects of LFS stimulation on the fEPSP initial slope. The gray area represents the duration of LFS (low-frequency stimulation, 900 pulses at 1 Hz) for 15 minutes. The number of slices (n) and mice (N) used in each experiment is indicated in parentheses. Error bars show the s.e.m.