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Figure 5 | Molecular Brain

Figure 5

From: Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

Figure 5

Synaptic properties of hippocampal slices from older (>10 weeks) WT and 1d2d-PSD-95-EGFP KI mice. A, LTP by high-frequency stimulation (100 Hz, 100 pulses) at Schaffer collaterals/commissural projections-CA1 synapse in WT (open circles, n = 7 slices from 3 mice) and KI (filled circles, n = 6 slices from 3 mice) mice. B, LTP by repeated tetanus stimulation in the continuous presence of picrotoxin (100 μM) at medial perforant path-DG synapses. Filled circles: KI mice (n = 8 slices from 4 mice). Open circles: WT littermates (n = 8 slices from 4 mice). Bars in A,B indicate the period of single/repeated high frequency stimulations. C, Basal transmission of medial perforant path-DG synapses. Filled circles: KI mice (n = 8 slices from 3 mice). Open circles: WT littermates (n = 8 slices from 3 mice). Fiber volley amplitude was plotted against the stimulus intensity in the left panel, and the initial fEPSP slope was plotted against the stimulus intensity in the right panel. D, PPR of the medial perforant path-DG synapses. Filled circles: KI mice (n = 5 slices from 3 mice). Open circles: WT littermates (n = 5 slices from 3 mice). E, PPR with 50 ms interstimulus interval of the medial perforant path-DG synapses of WT (open circles, n = 8 slices from 4 mice) and KI (filled circles, n = 10 slices from 4 mice) mice was measured before and after LTP induction. All values are expressed as mean ± SEM.

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