Table 1 General physical characteristics and sensory/motor functions of 1d2d-PSD-95-EGFP KI mice and their wild-type littermates

Physical characteristics

Weight (grams)

28.5 (± 0.8)

24.9 (± 0.5)

Rectal temperature (°C)

37.1 (± 0.2)

36.9 (± 0.2)

Grip strength

0.86 (± 0.019)

0.93 (± 0.029)

Sensory motor reflex

Acoustic startle response (arbitrary unit)

Stimulus intensity = 110 dB

0.9 (± 0.07)

0.5 (± 0.09)

Stimulus intensity = 120 dB

1.1 (± 0.07)

0.6 (± 0.08)

Prepulse inhibition (%; startle stimulus = 110 dB)

Prepulse intensity = 74 dB

32.1 (± 5.2)

38.2 (± 10.2)

Prepulse intensity = 78 dB

58.4 (± 4.0)

44.9 (± 9.7)

Pain test

Hot plate (latency; seconds)

9.2 (± 0.6)

8.9 (± 0.4)

Motor tests

Wire hang (latency to fall; seconds)

56.4 (± 1.9)

43.6 (±5.8)

Rotarod (latency to fall; averages of three trials)

Day 1

118.8 (± 21.0)

89.6 (± 16.2)

Day 2

183.3 (± 14.9)

151.3 (± 18.0)