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Figure 2 | Molecular Brain

Figure 2

From: Hippocampal function is not required for the precision of remote place memory

Figure 2

Place memory formation requires NMDA receptor function, CREB-mediated transcription, and protein synthesis in the hippocampus. A-E, Experimental design used with data presented below. A, Effect of an antagonist of the NMDA receptor on place memory formation. Motility in the first 3 minutes during the learning or testing session in chamber S. SAL (saline), CPP, or CPP treatment-only (homecage) groups. There was a significant interaction between adaptation and drug treatment (repeated ANOVA: F(1, 47) = 13.42, P < 0.01). n = 10-12/group. B, Effect of inducible repression of CREB function on place memory formation. Motility in the first 3 minutes during the learning or testing session in chamber S. There was a significant interaction between adaptation and genotype (repeated ANOVA: F(1, 31) = 7.32, P < 0.02). n = 6-9/group. C, Effect of i.p. injection of ANI on long-term place memory. Motility in the first 3 minutes during the learning or testing session in chamber S. SAL, ANI, or ANI treatment-only (homecage) groups. Injection of ANI disrupted long-term place memory. There was a significant interaction between adaptation and drug (repeated ANOVA: F(1, 47) = 15.89, P < 0.001). n = 10-12/group. D, Effect of i.p. injection of ANI on short-term place memory. Injection of ANI did not affect short-term place memory. n = 10/group. E, Effect of infusion of ANI into dorsal hippocampus on consolidation of place memory. There was a significant interaction between adaptation and drug (repeated ANOVA: F(1, 21) = 12.14, P < 0.001). n = 5-6/group. ***P < 0.001. **P < 0.01. *P < 0.05. Error bars indicate SEM.

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