Figure 4

The retrieval and precision of remote, but not recent, place memory does not require hippocampal function. A-E, Experimental design used with data presented below. A, Recent and remote place memory in CaMK II heterozygous null mutant (HKO) mice. Motility in the first 3 minutes during the learning and testing session. There was a significant interaction between adaptation and day (repeated ANOVA: F_{(1, 53)} = 36.55, P < 0.001). n = 13-14/group. B, C, Effect of the fluorescently-labeled muscimol (FCM) injection into the hippocampus on the formation (C) and the retrieval (B) of recent place memory. Motility in the first 3 minutes during the learning or testing session. There was a significant interaction between adaptation and drug (Figure 4B, repeated ANOVA: F_{(1, 29)} = 23.61, P < 0.001) (Figure 4C, repeated ANOVA: F_{(1, 33)} = 21.29, P < 0.001). D, Effect of FCM infusion into the hippocampus on the retrieval of remote and recent place memory. Chamber S was used for the remote memory retrieval test. Chamber C was used for the recent memory retrieval test. n = 10-11/group. E, Effect of the FCM infusion into the hippocampus on the retrieval of remote place memory in different chambers and rooms. Motility in the first 3 minutes during the learning or testing session. There was a significant interaction between adaptation and chamber (chamber S/Room A vs chamber C/Room A; repeated ANOVA: F_{(1, 39)} = 35.71, P < 0.001) (chamber S/Room A vs chamber S/Room B; repeated ANOVA: F_{(1, 43)} = 34.99, P < 0.001). n = 10-12/group. ***P < 0.001. Error bars indicate SEM.