Reconsolidation update eliminates NASPM sensitivity in ACC pyramidal neurons. (A) Reconsolidation update protocol. (B-D) Reconsolidation update robustly extinguishes trace fear memory recall. (E) We extracted the ACC of mice immediately following reconsolidation update of trace fear memory. (F-G) Reconsolidation update abolishes NASPM sensitivity of layer II/III pyramidal neurons in the ACC induced by trace fear memory conditioning, (FosGFP positive extinction: n = 4; FosGFP negative: n = 9, t = -2.38). (G includes FosGFP positive conditioning mean from Fig 5 for comparison). (* P < 0.02 ).