Effect of intra-CA1 inhibition of NR2B-NMDARs on win-shift failure and lose-Shift failure in T-maze delayed-alternation task. (A) Diagram showing the two types of performance errors in delayed-alternation T-maze task. Win-shift failure means that rats did not alter their choice after they made a correct selection in the previous trial, and Lose-Shift failure that the rats repeated an incorrect choice made in the previous trial. (B) Rats with intra-CA1 infusion of Ro25-6981, ifenprodil exhibited significantly more Win-shift failures relative to controls in 30-s delay (right), but not in 5-s delay (left), while NVP-AAM077-treated rats showed significantly more Win-shift failures in 5-s delay. *p<0.05, **p<0.01 vs. vehicle control, Mann-Whitney U-test. (C) Rats with intra-CA1 infusion of Ro25-6981, ifenprodil demonstrated significantly more Lose-shift failures in both 5-s (left) and 30-s delay (right), while NVP-AAM077-treated rats showed dramatically more Lose-shift failures in 5-s delay (left). **p<0.01 vs. the vehicle control, Mann-Whitney U-test.