From: Fragile X mental retardation protein and synaptic plasticity
Category | Region | Fragile X Mouse Phenotype | Age | References |
---|---|---|---|---|
mGluR LTD | hippocampus | enhanced | P25-30 | Huber et al., 2002; Hou et al., 2006; Bhattacharya et al., 2012; Michalon et al., 2012 |
mGluR LTD | hippocampus | does not require new protein synthesis | 4-12 wk | Nosyreva and Huber, 2006; Hou, et al., 2006; Zang et al., 2009** |
mGluR LTD | hippocampus | * enhanced and not PS-dependent | P35-42 | Iliff et al., 2012 |
mGluR LTD | cerebellum | enhanced | 3-7 wk | Koekkoek et al., 2005 |
mGluR LTD | hippocampus | enhanced and does not require new protein synthesis | 3-7 wk | Volk et al., J Neurosci, 2007 |
LTP | hippocampus | NONE | 20-26 wk; 8-10 wk; 3-12 month | Godfraind et al., 1996; Li et al., 2002; Larson et al., 2005 |
L-LTP | hippocampus | NONE | 5-7 wk; 2-4 month | Paradee et al., 1999; Zhang et al., J 2009 |
LTP | hippocampus | deficient | 2 wk; 6-8 wk | Hu et al., 2008; Shang et al., 2009 |
LTP | hippocampus | deficient with weak stimulus; normal with strong stimulus | 2-3 month | Lauterborn et al., 2007 |
LTP | hippocampus | enhanced B-adrenergic-facilitated heterosynaptic LTP (PS-dependent) | 3-4 month | Connor et al., 2011 |
LTP priming | hippocampus | does not require new protein synthesis (mGluR-dependent) | 6-10 wk | Auerbach and Bear, 2010 |
LTP | anterior cingulate ctx | deficient | 6-8 wk | Zhao et al., 2005; Xu et al., 2012 |
LTP | anterior cingulate ctx | impaired facilitation of LTP by 5-HT2AR agonist | 6-8 wk | Xu et al., 2012 |
LTP | somatosensory, temporal ctx | deficient | 8-10 wk; 3 month | Li et al., 2002; Hayashi et al., 2007 |
LTP | somatosensory ctx | delayed window for plasticity | P3-10 | Harlow et al., 2010 |
LTP | visual ctx | deficient (mGluR-dependent) | P13-25 | Wilson and Cox, 2007 |
LTP | anterior piriform ctx | deficient in aged mice; normal in 3-6 mo mice | 6-18 month | Larson et al., 2005 |
LTP | amygdala | impaired (mGluR-dependent) | 6-8 wk; 3.5-6 mo | Zhao et al., 2005; Suvrathan et al., 2010 |
STD-LTP | somatosensory ctx | deficient with weak stimulus | P10-18 | Desai et al., 2006 |
STD-LTP | prefrontal ctx | deficient with weak stimulus; normal with strong stimulus | P14-23 | Meredith et al., 2007 |
homeostasis | hippocampus | deficient translation-dependent scaling | P6-7 slice culture | Soden and Chen, 2010 |
homeostasis | hippocampus | normal transcription-dependent scaling | P6-7 slice culture | Soden and Chen, 2010 |
experience-dependent | visual ctx (in vivo) | altered ocular dominance plasticity | LTD | Dolen et al., 2007 |
experience-dependent | somatosensory ctx | deficient experience-dependent plasticity (induced by whisker trimming) | LTD | Bureau et al., 2008 |