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Table 1 Fragile X mouse synaptic plasticity phenotypes

From: Fragile X mental retardation protein and synaptic plasticity

Category Region Fragile X Mouse Phenotype Age References
mGluR LTD hippocampus enhanced P25-30 Huber et al., 2002; Hou et al., 2006; Bhattacharya et al., 2012; Michalon et al., 2012
mGluR LTD hippocampus does not require new protein synthesis 4-12 wk Nosyreva and Huber, 2006; Hou, et al., 2006; Zang et al., 2009**
mGluR LTD hippocampus * enhanced and not PS-dependent P35-42 Iliff et al., 2012
mGluR LTD cerebellum enhanced 3-7 wk Koekkoek et al., 2005
mGluR LTD hippocampus enhanced and does not require new protein synthesis 3-7 wk Volk et al., J Neurosci, 2007
LTP hippocampus NONE 20-26 wk; 8-10 wk; 3-12 month Godfraind et al., 1996; Li et al., 2002; Larson et al., 2005
L-LTP hippocampus NONE 5-7 wk; 2-4 month Paradee et al., 1999; Zhang et al., J 2009
LTP hippocampus deficient 2 wk; 6-8 wk Hu et al., 2008; Shang et al., 2009
LTP hippocampus deficient with weak stimulus; normal with strong stimulus 2-3 month Lauterborn et al., 2007
LTP hippocampus enhanced B-adrenergic-facilitated heterosynaptic LTP (PS-dependent) 3-4 month Connor et al., 2011
LTP priming hippocampus does not require new protein synthesis (mGluR-dependent) 6-10 wk Auerbach and Bear, 2010
LTP anterior cingulate ctx deficient 6-8 wk Zhao et al., 2005; Xu et al., 2012
LTP anterior cingulate ctx impaired facilitation of LTP by 5-HT2AR agonist 6-8 wk Xu et al., 2012
LTP somatosensory, temporal ctx deficient 8-10 wk; 3 month Li et al., 2002; Hayashi et al., 2007
LTP somatosensory ctx delayed window for plasticity P3-10 Harlow et al., 2010
LTP visual ctx deficient (mGluR-dependent) P13-25 Wilson and Cox, 2007
LTP anterior piriform ctx deficient in aged mice; normal in 3-6 mo mice 6-18 month Larson et al., 2005
LTP amygdala impaired (mGluR-dependent) 6-8 wk; 3.5-6 mo Zhao et al., 2005; Suvrathan et al., 2010
STD-LTP somatosensory ctx deficient with weak stimulus P10-18 Desai et al., 2006
STD-LTP prefrontal ctx deficient with weak stimulus; normal with strong stimulus P14-23 Meredith et al., 2007
homeostasis hippocampus deficient translation-dependent scaling P6-7 slice culture Soden and Chen, 2010
homeostasis hippocampus normal transcription-dependent scaling P6-7 slice culture Soden and Chen, 2010
experience-dependent visual ctx (in vivo) altered ocular dominance plasticity LTD Dolen et al., 2007
experience-dependent somatosensory ctx deficient experience-dependent plasticity (induced by whisker trimming) LTD Bureau et al., 2008
  1. LEGEND: Fragile X mouse models have multiple altered forms of synaptic plasticity across multiple brain regions. The majority of phenotypes were assessed in the Fmr1 KO mouse which lacks FMRP. *Assessed using a CGG knock-in mouse which models FX premutation. **Assessed using an FMRP point mutant mouse with disrupted FMRP-mRNA binding.