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Figure 7 | Molecular Brain

Figure 7

From: Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs

Figure 7

The loss of whisker inputs downregulates the transmission of inhibitory synapses on pyramidal neurons of the barrel cortex. The strength of inhibitory synapses was evaluated by recording spontaneous inhibitory postsynaptic currents (sIPSC) in the presence of 10 μM CNQX and 40 μM D-AP5, which were blocked by 10 μM bicuculine. A) shows sIPSCs recorded on a pyramidal neuron in the barrel cortex from a control mouse. B) shows sIPSCs recorded on a pyramidal neuron in the barrel cortex from a whisker-trimmed mouse. Calibration bars are 10 pA/3 seconds C) illustrates cumulative probability versus sIPSC amplitudes in barrel cortical pyramidal neurons from whisker-trimmed mice (open symbols, n=11) and controls (filled, n=12). D) illustrates cumulative probability versus inter-IPSC intervals in barrel cortical pyramidal neurons from whisker-trimmed mice (open symbols, n=11) and controls (filled, n=12).

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Molecular Brain

ISSN: 1756-6606