Differential alterations in CB- and PV-labeled interneurons in the mPFC and DLFC of Disc1 -L100P adult mice. (A) A representative section used for counting CB- and PV-labeled cell densities is shown with boxes depicting the areas analyzed for the mPFC and DLFC regions. Scale Bar, 500 μm. (B) Quantification of CB+ and PV+ cells in the mPFC showed significantly fewer PV-interneurons in the Disc1- L100P mutants but no significant difference with CB-interneurons when compared to WT (n = 13–14 from 4 mice per group; t-test, p < 0.01). (C) In contrast, Disc1- L100P mutants have significantly more CB+ cells but not PV+ cells in the DLFC versus WT (n = 21–22 from 4 mice per group, t-test, p < 0.05). All data are shown as mean ± SEM; * p < 0.05, ** p < 0.01 versus WT. CB, calbindin; DLFC, dorsal lateral frontal cortex; mPFC, medial prefrontal cortex; PV, parvalbumin.