Figure 5

Reduced GAD67/PV co-localization in Disc1- L100P adult mutants. (A) GAD67 (green) and PV (red) fluorescently labeled images in WT and Disc1- L100P mutants. White arrows indicate those with more than 50% overlap of GAD67 and PV. Scale Bar, 50 μm. (B) Quantification of the percentage of GAD67⁺PV⁺ cells per total PV⁺ cells revealed significantly less GAD67 expression within PV-cells in Disc1- L100P mice compared to WT (n = 106–128 ROIs from 4 different mice per group). All data are shown as mean ± SEM; ** p < 0.01 versus WT. GAD67, glutamic acid decarboxylase (67 kDa); PV, parvalbumin.