Figure 5
From: Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors
THIP inhibits CTZ-induced epileptiform activity and seizure behavior. Aa-d, Typical traces showing ‘silent’ baseline activity of hippocampal CA1 neurons in control condition (a), synchronized epileptiform bursting activities induced by CTZ (5 μmol) (b), inhibition of THIP (4 mg /kg) on burst activity (c), and the recovery after the THIP injection (d). Ae, Bar histogram showing group data of THIP inhibition on CTZ-induced epileptiform burst activities. B, Bar histogram showing group data of CTZ-induced (5 μmol) seizure behavioral score and its significant attenuation by pre-treatment with THIP (10 mg/kg). THIP(5): 5 mg/kg THIP; THIP(10): 10 mg/kg THIP. * p < 0.05 and ** p < 0.01 in comparison with CTZ injection alone; # p < 0.05 for recovery, in comparison with CTZ + THIP.