Figure 8
From: An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch
Graphic summary of major findings and significance. A, Working model illustrating multiple changes induced by knockdown of NL2, including reduced GABAergic synapses, reduced glutamatergic synapses, and reduced KCC2 expression, which results in increased intracellular Cl- concentration and more excitatory GABA function. B, Schematic drawing illustrating NL2 as a central player in regulating the excitation and inhibition balance in the brain.