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Figure 5 | Molecular Brain

Figure 5

From: Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons

Figure 5

LP 12 application results in the selective reduction of the surface expression of NR2B. A) CA1 hippocampal slices were treated with vehicle, 300 nM LP 12, or LP 12 + 1 μM SB 258719 for 5 min. The slices were biotinylated and lysates were incubated overnight with streptavidin beads. Data represent the average and standard error of 6 independent experiments. * p < 0.05 LP 12 vs. vehicle ANOVA analysis with Dunnett’s post-test. B) Total lysates or biotinylated samples were blotted using antibodies against NR2B or β-actin.

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Molecular Brain

ISSN: 1756-6606