Figure 8
From: Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development
Notch dependency of Dll1 signaling pathway in the monolayer formation and morphogenesis of BG. (A, B) Double staining for Hes5 (red) and BLBP (green) in Dll1(loxP/+)/hGFAP-Cre (A) and Dll1(loxP/loxP)/hGFAP-Cre (B) mice at P5. White arrows show Purkinje cells. Red arrowheads show BG. (C) Dll1 expressed in BG (green), not in interneurons (red), plays crucial roles in the monolayer formation and morphogenesis of BG due to its Notch1/2-RBPj signaling transduction activity. Yellow cells are PCs. Scale bars: 50 μm (A, B). EGL, external granular layer; IN, interneuron; PC, Purkinje cell; PCL, Purkinje cell layer.