Table 4 Top networks and biological functions of miRNAs dysregulated in sALS
Top network functions for predicted targets of miRNAs up-regulated in sALS | ||
Associated network functions | Score | |
Cellular development, nervous system development and function, tissue development | 3 | |
Cellular assembly and organization, lipid metabolism, nucleic acid metabolism | 2 | |
Top biological functions for predicted targets of miRNAs up-regulated in sALS | ||
| Â | P-value | No. of molecules |
Diseases and disorders | Â | |
Reproductive system disease | 2.13E-03-2.13E-03 | 2 |
Inflammatory response | 2.92E-03-2.92E-03 | 1 |
Cancer | 6.81E-03-4.35E-02 | 3 |
Hematological disease | 6.81E-03-6.81E-03 | 1 |
Immunological disease | 6.81E-03-6.81E-03 | 1 |
Molecular and cellular functions | Â | |
Antigen presentation | 2.92E-03-2.92E-03 | 1 |
Cell to cell signaling and interaction | 2.92E-03-2.92E-03 | 1 |
Physiological system development and function | Â | |
Hematological system development and function | 2.92E-03-2.92E-03 | 1 |
Immune cell trafficking | 2.92E-03-2.92E-03 | 1 |
Top network functions for predicted targets of miRNAs down-regulated in sALS | ||
Associated network functions | Score | |
Cancer, gastrointestinal disease, hepatic system disease | 26 | |
Cancer, reproductive system disease, connective tissue disorders | 24 | |
Cell death, cancer, cell cycle | 18 | |
Cancer, reproductive system disease, gastrointestinal disease | 18 | |
Reproductive system disease, cancer, cellular growth and proliferation | 11 | |
Top biological functions for predicted targets of miRNAs down-regulated in sALS | ||
| Â | P-value | No. of molecules |
Diseases and disorders | Â | |
Reproductive system disease | 4.31E-88-2.58E-03 | 93 |
Inflammatory disease | 3.04E-47-4.99E-02 | 55 |
Renal and urological disease | 3.04E-47-3.95E-03 | 52 |
Cancer | 6.09E-41-4.40E-02 | 81 |
Gastrointestinal disease | 1.44E-21-1.25E-02 | 48 |
Molecular and cellular functions | Â | |
Cellular development | 1.51E-07-4.40E-02 | 22 |
Cellular growth and proliferation | 1.51E-07-4.99E-02 | 31 |
Cell cycle | 2.16E-05-4.40E-02 | 11 |
Cellular movement | 5.09E-04-4.99E-02 | 15 |
Cell death | 7.84E-04-4.10E-02 | 12 |
Physiological system development and function | Â | |
Organismal development | 2.33E-11-6.61E09 | 7 |
Connective tissue development and function | 2.16E-05-2.16E-05 | 4 |
Hair and skin development and function | 8.96E-03-8.96E-03 | 1 |
Nervous system development and function | 8.96E-03-8.96E-03 | 1 |
Respiratory system development and function | 8.96E-03-3.54E-02 | 3 |