Figure 5

Male GSK3α.KO mice are infertile. A. Breeding performance of GSK3α.KO mice versus FvB mice, estimated as number of pups and number of litters over a period of 111 days from 5 breeding couples/genotype). B. Testis weight, sperm cell counting and motility index assessed in males (n=5). All data (mean±SEM) are statistically analyzed by unpaired Student’s t-test (two-tailed): Testis weight, * p=0.030; sperm cells, p=0.198; motility index, * p=0.032. The red symbols in panels A and B represent a sterile FvB male. C. Sperm cells from GSKα.KO and FvB wild-type mice. Inset: single sperm at higher magnification.