Table 1 Motor ability, cognition and pain sensitivity of AA- and AAC mice (age 3–4 mo)
Task | Parameter (units) | AA- | AAC | p |
|---|---|---|---|---|
Motor | ||||
Inverted grid | Time (sec) | 60.00±0.00 | 58.40±1.60 | N/A |
Beamwalk | Time (sec) | 180.00±0.00 | 171.80±8.25 | N/A |
Behavior & cognition | ||||
Y-maze | Index | 75.06±2.59 | 69.42±2.69 | 0.1475 |
Entries (n) | 27.91±2.55 | 26.75±1.54 | 0.6956 | |
Alterations (n) | 19.55±2.11 | 17.08±1.12 | 0.3031 | |
OFT | Corners (sec) | 338.60±24.53 | 312.30±23.31 | 0.4469 |
Periphery (sec) | 556.70±8.67 | 561.70±5.89 | 0.6331 | |
Center (sec) | 43.36±8.67 | 38.36±5.89 | 0.6331 | |
Distance moved (cm) | 3972±444.4 | 4327±397.0 | 0.5573 | |
Mobility (%) | 66.77±4.02 | 68.75±4.23 | 0.7385 | |
Dark/Light | Latency (sec) | 52.27±24.46 | 55.17±24.84 | 0.9348 |
Transitions (n) | 4.18±0.74 | 4.33±0.75 | 0.8872 | |
Time spent in light (sec) | 106.60±28.04 | 89.00±15.24 | 0.5776 | |
Porsolt swim test | Immobility (%) | 53.96±4.78 | 49.55±3.70 | 0.4673 |
* NORT | Index | 59.56±3.78 | 45.82±3.76 | 0.0176 |
Distance moved (cm) | 2158±293.4 | 2040±273.4 | 0.7712 | |
Mobility (%) | 37.05±4.04 | 33.78±3.96 | 0.5708 | |
PIA | Latency to dark (sec) | 180.50±36.35 | 248.60±25.77 | 0.1334 |
Pain sensitivity | ||||
Footshock threshold | Flinching (mA) | 0.1350±0.0183 | 0.1792±0.0208 | 0.1347 |
Jumping (mA) | 0.4833±0.0546 | 0.6042±0.0711 | 0.2189 | |
Vocalizations (mA) | 0.3300±0.0300 | 0.3875±0.0418 | 0.2948 | |
* Hot plate task | Time (sec) | 8.90±0.74 | 6.92±0.43 | 0.0256 |
* Capsaicin sensitivity | Wipes (n) | 60.33±5.82 | 82.91±5.75 | 0.0136 |