Table 2 Motor ability and cognition of young female GSK3α.KO and GSK3α.KOxTau.P301L mice

* Rotarod

Time (sec)

299.4±0.6

300.0±0.0

NA

293.3±5.5

254.6±17.4

0.0268

* Y-maze

Index

66.95±1.66

71.15±4.84

0.3553

69.91±3.46

62.80 ±5.28

0.2600

*

Entries (n)

42.22±2.84

23.17±2.06

0.0003

45.10±1.49

27.38±3.18

<0.0001

*

Alterations (n)

26.89±1.88

15.00±1.67

0.0007

30.10±1.74

16.13±2.16

0.0001

* OFT

Corners (sec)

292.7±11.6

380.0±28.9

0.0070

282.3±11.10

337.8±29.6

0.0745

Periphery (sec)

549.9±8.08

572.8±7.08

0.0677

539.0±6.55

554.8±11.09

0.2169

Center (sec)

50.15±8.08

27.19±7.08

0.0677

61.02±6.55

45.22±11.09

0.2169

*

Distance (cm)

5972±303.7

3315± 389.6

0.0001

6500±341.3

3178±442.2

<0.0001

*

Mobility (%)

74.12±1.41

53.00±4.59

0.0002

77.72±1.09

55.08±5.95

0.0007

* NORT

Index

77.21±4.61

69.71±1.25

0.2189

78.46±1.90

59.91±7.14

0.0075

*

Distance (cm)

4017±263.5

2319± 329.9

0.0014

4459±303.6

1924±411.6

0.0002

*

Mobility (%)

66.78±1.96

44.86±5.09

0.0005

71.49±2.03

41.91±7.88

0.0005

* Dark/Light

Latency (sec)

21.67±4.90

27.33±3.99

0.4242

19.20±4.25

11.88±2.97

0.1985

*

Transitions (n)

11.11±1.01

6.17±1.05

0.0059

11.00±0.54

4.625±0.80

<0.0001

*

Time in light (sec)

150.40±4.49

132.5±29.08

0.4669

139.30±6.51

74.88±17.52

0.0018