Figure 3

Recovery of impaired neurites in LPS-injected SNpc. (A, C) At the indicated times after LPS injection, sections were labeled with antibodies specific for markers of MAP2 (A) and tyrosine hydroxylase (TH) (C). Lower panels are higher magnification images of boxed areas in upper panels. Arrows in lower panels in (C) indicate TH⁺ cell bodies. (B) MAP2-negative areas at 3 and 14 d after LPS injection were quantified. Values are means ± SEMs of more than three samples (*p < 0.01; Student’s t-test). Asterisks (*) indicate injection sites. (C) In contralateral (contra) sides and PBS-injected brains, TH⁺ dopaminergic neuronal cell bodies were detectable (white arrows), but TH⁺ dopaminergic neuronal cell bodies and processes were injured at 3 d after LPS injection. At 14 d and 2 mo, only processes reappeared (white arrowheads). Scale bars, 1 mm (upper panels in A, C), and 100 μm (lower panels in A, C).