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Figure 1 | Molecular Brain

Figure 1

From: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1

Figure 1

Enhanced expression of GABAB receptor subunits by NgR1 siRNA is prevented by rapamycin. Hippocampal neurons (DIV 14–17) treated with csiRNA or NgR1 siRNA. A. NgR1 siRNA significantly increased GABAB R1 and GABAB R2 protein levels. B. GABAA and GAD65 levels were unchanged. C. Knock down of NgR1 expression by NgR1 siRNA but not by csiRNA or NogoA siRNA used as controls. D. Rapamycin (100 nM) prevented the increased expression of GABAB R1 and GABAB R2 caused by NgR1 siRNA. Each sample was calculated as a ratio to β-actin and presented as percentage of control. * P < 0.05 and ** P < 0.01.

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