The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

Table 1 Profiles of individual ALS and control cases in this study

Patient	Sex/Age (y)	Disease	Duration of illness (months)	Duration on respirator (months)	TDP-43 cytoplasmic aggregation in spinal motor neurons	Cause of death	Postmortem delay until resection (min)	Number of spinal motor neurons examined in this study
A	Female / 66	sporadic ALS	38	26	+	Pneumonitis	82	74
B	Male / 59	sporadic ALS	45	26	+	empyema	113	104
C	Female / 76	sporadic ALS	39	18	+	pneumonitis	127	93
D	Male / 76	sporadic ALS	12	-	+	pneumonitis	112	92
E	Male / 83	sporadic ALS	27	-	+	pneumonitis	123	143
F	Female / 79	sporadic ALS	31	-	+	pneumonitis	240	127
C1	Female / 79	acute myocardial infarction	-	-	-		97	64
C2	Male / 87	Alzheimer’s disease, lung cancer, hypertension	-	-	-		240	47
C3	Female / 86	dementia, acute myocardial infarction, hypertension	-	-	-		240	43
C4	Female / 81	colon cancer, post-cerebral infarction	-	-	-		128	36
C5	Male / 78	metastatic brain tumor	-	-	-		103	100
C6	Male / 88	dementia	-	-	-		250	49

The average ages in ALS and control cases were 73.2 ± 8.9 y and 83.2 ± 4.4 y, respectively. All ALS cases in this study showed TDP-43 cytoplasmic aggregation in the spinal cord. Age, age of the patient at death; Patient A-F, individuals with ALS; C1-C5, normal controls with no neurological disorder affecting the spinal cord.

ISSN: 1756-6606