Stage 0 | TDP-43 is normally distributed within the well-marginated nucleus. | |||
---|---|---|---|---|
Stage I | The nucleus degradated, and TDP-43 was also seen in the cytoplasm. | |||
Stage II | The nuclear TDP-43 was so cleared that it was not recognized.The plasma membrane was still retained. | |||
Stage III | The plasma membrane disappeared. | |||
TDP-43 distribution | nuclear membrane | plasma membrane | ||
in the nucleus | in the cytoplasm | |||
Stage 0 | + | - | + | + |
Stage I | + | + | ± | + |
Stage II | ND | + | - | + |
Stage III | ND | ND | - | - |