Figure 6
Tonic activation of GABA A Rs has a weaker impact on excitability of Ts65Dn cerebellar granule cells. (A) Values of rheobase (minimum current-density required to initiate AP firing) before and during block of GABAARs with SR95531, in wild-type (*p < 0.0001, Wilcoxon matched pairs test; n = 24) and Ts65Dn (*p = 0.0005, Wilcoxon matched pairs test; n = 13) GCs. Overlapping points are horizontally offset. (B) Box plots comparing the change in rheobase induced by the application of SR95531 in wild-type and Ts65Dn GCs (*p = 0.0145, Mann Whitney U test). (C) Dependence of AP frequency (mean ± SEM) on magnitude of injected current-density above rheobase in the absence (filled symbols) and presence (empty symbols) of SR95531, in wild-type and Ts65Dn GCs (WT, n = 24 – 12; Ts65Dn, n = 13 – 5).