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Figure 3 | Molecular Brain

Figure 3

From: Homeostatic regulation of spontaneous and evoked synaptic transmission in two steps

Figure 3

Synaptic potentiation and connectivity are enhanced following reactivation. A, Cumulative histogram indicating mEPSCs recorded during 5 minute periods immediately before (gray) and 30 minutes after (black) a period of recurrent activation in control cultures (n = 16 cultures, one cell per culture). Insets show samples of the membrane current records (scale bars: 1 s, 25 pA). B, Same as A, but for TTX-treated networks (n = 7 cultures, one cell per culture). Thus, gray follows inactivation alone and black follows reactivation. C, Summary data for the increase in mEPSC amplitude after (re)activation. ‶ + AP5″ in category label indicates acute application of AP5 during washout of TTX. D, Similar to C, except showing the increase in mEPSC log-frequency, illustrating that the potentiation is reflected as in increase in both the amplitude and frequency of mEPSCs. E, Following (re)activation, an eEPSC is more probable in TTX-treated cultures, but F, The amplitudes of these responses are similar to those of controls. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001.

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