Figure 2

PAR1 activation does not generate mEPSCs. A. Hippocampal slices were pretreated with concanamycin A (2 μM ; ~2 hr) to minimize presynaptic glutamate release. The representative traces indicate mEPSCs from the concanmycin A pretreated slices before TFLLR treatment and after treatment, respectively. Asterisk shows mEPSCs. Right : expanded mEPSC traces from basal or TFLLR-treated slices. B. Bar graphs represent the averaged amplitudes and frequencies of mEPSCs. Numbers of tested slices from at least two independent mice are indicated in the bar graph. P-value : 0.216 (amplitude), 0.853 (frequency).